here

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/413815#:~:text=In%20conclusion%2C%20physical%20activity%20in,smoking%2C%20BMI%2C%20or%20SES.

他们做了全组对照，也做了双胞胎组对照， 也confirm了一样的finding。

This finding was confirmed in a small group of twin pairs discordant for physical activity level (on average, the LTL of more active twins was 88 nucleotides longer than that of less active twins; P = .03).